1: N-(2-cyanoethyl)-L-valine With sodium hydroxide in water pH=9.5 - 10.5; 2: methyl chloroformate With sodium hydroxide in water T=20 - 25°C; pH=9.0 - 10.5;
参考文献
CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A.
Patent: WO2003/101971 A1, 2003 ;
Location in patent: Page 7 ;
1: 2-aminoisovaleric acid With potassium hydroxide in water T=20 - 25°C; 0.75 - 0.833333 h; 2: acrylonitrile in water T=0 - 5°C; 5.33333 h; 3: methyl chloroformate With hydrogenchloride; sodium hydroxide; water more than 3 stages;
1: phenyl chloroformate With potassium hydroxide in water T=0°C; 2: acrylonitrile T=0 - 5°C; 4.5 h; 3: methyl chloroformate With potassium hydroxide in water pH=9.5 - 10.5;