11-alpha-羟基坎利酮合成路线 （共 5 条）
反应条件
D-glucose; peptone in water
参考文献
G.D. SEARLE and CO.
Patent: EP1223174 A2, 2002 ;
Location in patent: Example 16 ;
反应条件
Aspergillus ochraceus SIT34205 T=28°C; 50 h;
参考文献
Chinese Chemical Letters, , vol. 23, # 3 p. 313 - 316
反应条件
1.1: potassium carbonate; dimethyloctadecylbenzylammonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: potassium formiate; formic acid / acetic anhydride / 100 °C View Scheme
参考文献
Zhang, Bin; Chen, Hongli; Tang, Huanyu; Feng, Huijin; Li, Yuanchao
Steroids, 2012 , vol. 77, # 11 p. 1086 - 1091
反应条件
1.1: potassium carbonate; dimethyloctadecylbenzylammonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0 °C 5.1: potassium formiate; formic acid / acetic anhydride / 100 °C 6.1: .alpha.,.alpha.,.alpha.-trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme
参考文献
Zhang, Bin; Chen, Hongli; Tang, Huanyu; Feng, Huijin; Li, Yuanchao
Steroids, 2012 , vol. 77, # 11 p. 1086 - 1091
反应条件
1.1: potassium carbonate; dimethyloctadecylbenzylammonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C View Scheme
参考文献
Zhang, Bin; Chen, Hongli; Tang, Huanyu; Feng, Huijin; Li, Yuanchao
Steroids, 2012 , vol. 77, # 11 p. 1086 - 1091
