(S)-1-Cbz-吡咯烷-3-甲酸合成路线 （共 17 条）
反应条件
1: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C 2: 90 percent / CrO3 / acetone / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: NEt3, DMAP / CH2Cl2 / 2 h / 0 °C 2: 80 percent / dimethylsulfoxide / 4 h / 80 °C 3: 65 percent / HCl / methanol; H2O / 72 h / Ambient temperature View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1773 - 1778
反应条件
1: 68 percent / BH3*Me2S / tetrahydrofuran / 20 °C 2: 82 percent / H2O2; aq. LiOH / tetrahydrofuran / 2.5 h / 0 °C View Scheme
参考文献
Synthesis, , # 11 art. no. T12704SS, p. 1829 - 1837
反应条件
1: 96 percent / TFA / CH2Cl2 / 20 °C 2: 68 percent / BH3*Me2S / tetrahydrofuran / 20 °C 3: 82 percent / H2O2; aq. LiOH / tetrahydrofuran / 2.5 h / 0 °C View Scheme
参考文献
Synthesis, , # 11 art. no. T12704SS, p. 1829 - 1837
反应条件
1: NEt3 / CH2Cl2 / 2 h / 0 °C 2: NEt3, DMAP / CH2Cl2 / 2 h / 0 °C 3: 80 percent / dimethylsulfoxide / 4 h / 80 °C 4: 65 percent / HCl / methanol; H2O / 72 h / Ambient temperature View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1773 - 1778
反应条件
1: 80 percent / dimethylsulfoxide / 4 h / 80 °C 2: 65 percent / HCl / methanol; H2O / 72 h / Ambient temperature View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1773 - 1778
反应条件
1.1: dimethyl sulfoxide / 21 h / 80 °C / Inert atmosphere 2.1: hydrogenchloride; water / 4.5 h / Reflux 2.2: 7 h / 0 - 20 °C 2.3: pH 2 View Scheme
