(S)-1-Cbz-吡咯烷-3-甲酸合成路线 （共 17 条）
反应条件
1: (+)-(S)-3-cyanopyrrolidine-1-carboxylic acid benzyl ester With hydrogenchloride; water 4.5 h; Reflux; 2: benzyl chloroformate With sodium carbonate in water; acetone T=0 - 20°C; 7 h; 3: With hydrogenchloride; potassium hydrogensulfate in water pH=2;
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
Location in patent: Page/Page column 62 ;
反应条件
chromium(VI) oxide in acetone T=0°C;
参考文献
Mazzini; Lebreton; Alphand; Furstoss
Journal of Organic Chemistry, 1997 , vol. 62, # 15 p. 5215 - 5218
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 2.5 h;
参考文献
Stoncius, Arvydas; Nahrwold, Markus; Sewald, Norbert
Synthesis, 2005 , # 11 art. no. T12704SS, p. 1829 - 1837
反应条件
hydrogenchloride in methanol; water 72 h; Ambient temperature;
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
反应条件
1: 95 percent / H2 / Pd/C / ethanol / 24 h 2: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C 3: 90 percent / CrO3 / acetone / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 95 percent / LAH / tetrahydrofuran / 0 deg C to reflux 2: 95 percent / DMAP, Et3N / CH2Cl2 / 0.5 h / 0 °C 3: 85 percent / Et3N / dioxane / 12 h / Heating 4: 95 percent / H2 / Pd/C / methanol / 24 h 5: 95 percent / H2 / Pd/C / ethanol / 24 h 6: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C 7: 90 percent / CrO3 / acetone / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 95 percent / DMAP, Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 85 percent / Et3N / dioxane / 12 h / Heating 3: 95 percent / H2 / Pd/C / methanol / 24 h 4: 95 percent / H2 / Pd/C / ethanol / 24 h 5: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C 6: 90 percent / CrO3 / acetone / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 85 percent / Et3N / dioxane / 12 h / Heating 2: 95 percent / H2 / Pd/C / methanol / 24 h 3: 95 percent / H2 / Pd/C / ethanol / 24 h 4: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C 5: 90 percent / CrO3 / acetone / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
1: 95 percent / H2 / Pd/C / methanol / 24 h 2: 95 percent / H2 / Pd/C / ethanol / 24 h 3: 90 percent / aq. K2CO3 / tetrahydrofuran / 4 h / 0 °C 4: 90 percent / CrO3 / acetone / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 15 p. 5215 - 5218
反应条件
ethylenediaminetetraacetic acid in phosphate buffer T=30°C; pH=8.00; 18 h; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 8-9 p. 1475 - 1480
