5-甲基-2-噻吩甲酸合成路线

参考文献

SUNESIS PHARMACEUTICALS, INC.
Patent: WO2006/65703 A1, 2006 ;
Location in patent: Page/Page column 128 ;
WO 2006/065703 A1

1918-79-25-甲基-2-噻吩甲酸+

74-88-4甲基碘

19432-69-05-甲基噻吩-2-羧酸甲酯

参考文献

Japan Tobacco Inc.
Patent: EP1688420 A1, 2006 ;
Location in patent: Page/Page column 131 ;

1918-79-25-甲基-2-噻吩甲酸

19432-69-05-甲基噻吩-2-羧酸甲酯

参考文献

SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
Location in patent: Page/Page column 16 ;
US 20120245178 A1

186581-53-3重氮甲烷+

1918-79-25-甲基-2-噻吩甲酸

19432-69-05-甲基噻吩-2-羧酸甲酯

参考文献

Lozanova, A. V.; Moiseenkov, A. M.; Semenovskii, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 619 - 623
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 838 - 842

7647-01-0盐酸+

67-56-1甲醇+

1918-79-25-甲基-2-噻吩甲酸

19432-69-05-甲基噻吩-2-羧酸甲酯

参考文献

Imoto et al.
Nippon Kagaku Zasshi, 1956 , vol. 77, p. 804,807
Chem.Abstr., 1958 , p. 9066

1918-79-25-甲基-2-噻吩甲酸

689-89-4山梨酸甲酯+

71624-92-5+

13894-61-6(E)-己-3-烯酸甲酯+

14017-81-3+

13894-62-7甲基(3Z)-3-己烯酸酯+

86610-45-9

参考文献

Blenderman, Walter G.; Joullie, Madeleine M.; Preti, George
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3206 - 3213

1918-79-25-甲基-2-噻吩甲酸

70624-30-52-(5-甲基噻吩-2-基)乙酸

参考文献

Abbott Laboratories
Patent: US5486525 A1, 1996 ;

1918-79-25-甲基-2-噻吩甲酸

75985-18-1甲基5-(氨基甲基)噻吩-2-羧酸酯

参考文献

Choong, Ingrid C.; Lew, Willard; Lee, Dennis; Pham, Phuongly; Burdett, Matthew T.; Lam, Joni W.; Wiesmann, Christian; Luong, Tinh N.; Fahr, Bruce; DeLano, Warren L.; McDowell, Robert S.; Allen, Darin A.; Erlanson, Daniel A.; Gordon, Eric M.; O'Brien, Tom
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5005 - 5022

1918-79-25-甲基-2-噻吩甲酸

830331-52-7

参考文献

Rueckle, Thomas; Biamonte, Marco; Grippi-Vallotton, Tania; Arkinstall, Steve; Cambet, Yves; Camps, Montserrat; Chabert, Christian; Church, Dennis J.; Halazy, Serge; Jiang, Xuliang; Martinou, Isabelle; Nichols, Anthony; Sauer, Wolfgang; Gotteland, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6921 - 6934

1918-79-25-甲基-2-噻吩甲酸

66117-23-5

参考文献

Campaigne; Grose
Journal of the American Chemical Society, 1951 , vol. 73, p. 3812