(2E)-3-(3,4-二甲氧基苯基)-1-(2-羟基苯基)-2-丙烯-1-酮合成路线 （共 16 条）
反应条件
1: o-hydroxyacetophenone With sodium hydride in tetrahydrofuran; mineral oil Inert atmosphere; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran; mineral oil T=20°C; Aldol condensation; 16.25 h; 3: With hydrogenchloride in tetrahydrofuran; water; mineral oil
参考文献
Sagrera, Gabriel; Bertucci, Ana; Vazquez, Alvaro; Seoane, Gustavo
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3060 - 3073
反应条件
1H-imidazole; 18-crown-6 ether; sodium hydride in tetrahydrofuran; benzene 20 h;
参考文献
Katagi, Toyoshi; Shirota, Taeko; Kashiwagi, Masako; Hayashi, Kayo
Heterocycles, 1981 , vol. 15, # 1 p. 493 - 494
反应条件
selenium(IV) oxide in 3-methyl-1-butanol T=140 - 150°C; 14 h;
参考文献
Ahmed; Khan; Alam
Pharmazie, 2003 , vol. 58, # 3 p. 173 - 176
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane 72 h; Heating;
参考文献
Imafuku, Kimiaki; Honda, Masaaki; McOmie, J. F. W.
Synthesis, 1987 , # 2 p. 199 - 201
反应条件
1H-1-hydroxy-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide in methanol 24 h; Reflux;
参考文献
Justik, Michael W.; Zimmerman, Alyssa K.
Heterocyclic Communications, 2009 , vol. 15, # 1 p. 67 - 71
反应条件
pyrimidolt;5,4-ggt;pteridine N-oxide deriv in acetonitrile 0.833333 h; Ambient temperatureIrradiation;
参考文献
Maki, Yoshifumi; Shimada, Kaoru; Sako, Magoichi; Hirota, Kosaku
Tetrahedron, 1988 , vol. 44, # 11 p. 3187 - 3194
反应条件
1: 73 percent / SeO2 / 3-methyl-butan-1-ol / 14 h / 140 - 150 °C 2: 41 percent / AlCl3 / acetonitrile / 3 h / Heating View Scheme
参考文献
Ahmed; Khan; Alam
Pharmazie, 2003 , vol. 58, # 3 p. 173 - 176
反应条件
sodium tetrahydroborate; nickel dichloride in 1,4-dioxane; methanol
T=5 - 10°C;
参考文献
Dhawan; Grover
Synthetic Communications, 1992 , vol. 22, # 16 p. 2405 - 2409
反应条件
sodium hydroxide; dihydrogen peroxide in ethanol; water
Algar-Flynn-Olyamada (AFO) reaction;
参考文献
Li, Zhitao; Ngojeh, George; DeWitt, Paul; Zheng, Zhi; Chen, Min; Lainhart, Brendan; Li, Vincent; Felpo, Peter
Tetrahedron Letters, 2008 , vol. 49, # 51 p. 7243 - 7245
反应条件
1: H2 / 10percent Pd-C / tetrahydrofuran / Ambient temperature
2: 74 percent / Na / 6 h / Heating
View Scheme
参考文献
Kirkiacharian, Serge; Tongo, Hubert G.; Bastide, Janine; Bastide, Pierre; Grenie, Marie Magdeleine
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 541 - 546
