2,3-二氢-3,3-二甲基-1H-吲哚合成路线 （共 27 条）
反应条件
sulfuric acid; nitric acid T=0°C; 0.0833333 h; Yield given;
参考文献
Edwards, James P.; West, Sarah J.; Pooley, Charlotte L. F.; Marschke, Keith B.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 745 - 750
参考文献
Brunner
Monatshefte fuer Chemie, 1897 , vol. 18, p. 120
反应条件
1: 70percent aq. HNO3, H2SO4 / 0.08 h / 0 °C 2: H2 / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 7 p. 745 - 750
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene
T=75°C; 0.75 h;
参考文献
Kucerovy; Hathaway; Mattner; Repic
Synthetic Communications, 1992 , vol. 22, # 5 p. 729 - 733
反应条件
sodium tetrahydroborate; water; sodium hydroxide in n-heptane
T=10°C; pH=~ 13; 3 h;
参考文献
AMGEN INC.; KING, Anthony; LARSEN, Robert; LI, Tj; LU, Yuelie
Patent: WO2010/71828 A2, 2010 ;
Location in patent: Page/Page column 13 ;
反应条件
1: With hydrogenchloride in methanol
T=50°C; 16 h;
2: With water
pH=8;
参考文献
GLAXOSMITHKLINE LLC; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILIP, Joanne; ZHAO, Yongdong
Patent: WO2011/88027 A1, 2011 ;
Location in patent: Page/Page column 76 ;
反应条件
tetrabutyl-ammonium chloride; sodium formate; triethylamine; palladium diacetate in N,N-dimethyl-formamide
T=80°C; 24 h;
参考文献
Larock, Richard C.; Babu, Srinivasan
Tetrahedron Letters, 1987 , vol. 28, # 44 p. 5291 - 5294
反应条件
palladium diacetate; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=90°C;
参考文献
Edwards, James P.; West, Sarah J.; Pooley, Charlotte L. F.; Marschke, Keith B.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 745 - 750
反应条件
copper(l) iodide; triethylamine in N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
Erdelmeier; Tailhan-Lomont; Yadan
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8152 - 8157
反应条件
Rh2(esp)2 in toluene
T=120°C; 16 h; Inert atmosphere;
参考文献
Nguyen, Quyen; Sun, Ke; Driver, Tom G.
Journal of the American Chemical Society, 2012 , vol. 134, # 17 p. 7262 - 7265
