反应条件
1: N-chlorosuccinimide, AgNO3, 2,6-lutidine / acetonitrile / 5 min water bath cooling, 45 min stirring 2: LiAlH4 / diethyl ether; tetrahydrofuran / 24 h 3: pyridine / 16 h / 0 °C 4: 60 percent / ethanol; H2O / 1.) add KCN, 0 grad C; 2.) stir overnight, room temp. 5: BH3 / tetrahydrofuran / 1.) add BH3 over 14 min, 0 grad C; 2.) stir 2 h 6: aq. NaOH, 30percent aq. H2O2 / 1 h / 40 °C 7: 1.) 3N aq. NaOH; 2.) 4N aq. H2SO4 / 1.) ca 100 deg C, 20 h; 2.) cool with ice View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 30 p. 2859 - 2862
