1: With pyridine; phosphorus pentachloride in dichloromethane T=20°C; 0.5 h; 2: (7R,8R)-7-phenylacetamido-3-[propen-1-yl]-3-cephem-4-carboxylic acid p-methoxybenzyl ester in dichloromethane 2 h; 3: With Propylene glycol; water; ortho-cresol more than 3 stages;