1-(1-苯并呋喃-5-基)乙酮合成路线 （共 7 条）
反应条件
1: 5-Bromobenzo(b)-furan With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: N,N-dimethyl acetamide in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 16 ;
US 20120277224 A1
反应条件
L-ERYTHRO-(1R,2S)-2-AMINO-1-PHENYLPROPAN-1-OL in toluene 1 h; Reflux;
参考文献
KOWA COMPANY, LTD.
Patent: US2010/280013 A1, 2010 ;
Location in patent: Page/Page column 51 ;
反应条件
quinoline; copper T=200°C; 6 h;
参考文献
Kowa Co., Ltd.
Patent: EP1602655 A1, 2005 ;
Location in patent: Page/Page column 12 ;
参考文献
Sumitomo Pharmaceutical Company, Limited
Patent: US6100260 A1, 2000 ;
反应条件
dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium; potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide T=140°C; Inert atmosphere;
参考文献
Oberholzer, Miriam; Gerber, Roman; Frech, Christian M.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 627 - 641
反应条件
1.1: polyphosphoric acid / toluene / 3 h / Reflux 2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 °C View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 140 °C 2.1: polyphosphoric acid / toluene / 3 h / Reflux 3.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere 3.2: 1 h / -78 °C View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
