氯[3-(二甲基氨基)丙基]镁合成路线 （共 34 条）
反应条件
1: With ethyl bromide; iodine; magnesium in tetrahydrofuran T=70°C; 0.25 h; 2: 1-dimethylamino-3-chloropropane in tetrahydrofuran T=68 - 70°C; Heating / reflux;
参考文献
JUBILANT ORGANOSYS LIMITED
Patent: WO2005/77927 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: With potassium hydroxide in water T=0 - 5°C; 2: With iodine; magnesium in tetrahydrofuran T=100 - 110°C; 4 h; Reflux;
参考文献
L. MOLTENI and C. DEI FRATELLI ALITTI - SOCIETA' DI ESERCIZIO S.P.A.; DEI, Donata; RONCUCCI, Gabrio; SOLDAINI, Gianluca; NISTRI, Daniele; CHITI, Giacomo; MUNICCHI, Moira; FANTETTI, Lia; GIULIANI, Francesco
Patent: WO2013/21338 A1, 2013 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
magnesium; 1,1-dibromo ethane in tetrahydrofuran
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5116863 A1, 1992 ;
US 5116863 A
反应条件
magnesium; 1,1-dibromo ethane in tetrahydrofuran; diethyl ether
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5116863 A1, 1992 ;
US 5116863 A
反应条件
ammonium chloride in tetrahydrofuran; water
参考文献
A. H. Robins Company, Incorporated
Patent: US3978129 A1, 1976 ;
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Calgon Corporation
Patent: US4044054 A1, 1977 ;
反应条件
in tetrahydrofuran; water; benzene
参考文献
Merck and Co., Inc.
Patent: US3972936 A1, 1976 ;
反应条件
in tetrahydrofuran; toluene T=-60°C; 0.25 h; Product distribution / selectivity;
参考文献
SANDOZ AG
Patent: WO2007/82771 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: 4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile With methyl boronic acid in toluene T=20 - 70°C; 0.75 h; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran; toluene T=-60°C; 0.2 h; Product distribution / selectivity;
参考文献
SANDOZ AG
Patent: WO2007/82771 A1, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
1: 4-(4-fluorobenzoyl)-3-(hydroxymethyl)benzonitrile With (1S,2R)-(+)-N-methylephedrine in toluene T=20 - 70°C; 0.75 h; 2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran; toluene T=-80°C; 0.2 h; Product distribution / selectivity;
参考文献
SANDOZ AG
Patent: WO2007/82771 A1, 2007 ;
Location in patent: Page/Page column 21 ;
