3,6-二氯-4-甲基哒嗪合成路线 （共 32 条）
反应条件
1: With trichlorophosphate 4 h; Inert atmosphereReflux; 2: With sodium hydrogencarbonate in water pH=6; Cooling with ice;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 5 p. 1644 - 1658
反应条件
trichlorophosphate in water; acetonitrile
反应条件
1.1: acetic acid; hydrazine / ethanol; water / 24 h / pH 6.5 / Cooling with ice; Reflux 2.1: trichlorophosphate / 4 h / Inert atmosphere; Reflux 2.2: pH 6 / Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 5 p. 1644 - 1658
反应条件
potassium dichromate
参考文献
Kuraishi
Pharmaceutical Bulletin, 1957 , vol. 5, p. 587,588
反应条件
1: methanol 2: aqueous NH3 / 130 - 150 °C 3: palladium/charcoal; aqueous NH3 / Hydrogenation View Scheme
参考文献
Takahayashi
Pharmaceutical Bulletin, 1957 , vol. 5, p. 229,233
反应条件
1: With potassium permanganate; potassium hydroxide in acetonitrile T=20°C; 6.5 h; Inert atmosphere; 2: With hydrogenchloride in acetonitrile pH=1;
参考文献
Liscio, Paride; Carotti, Andrea; Asciutti, Stefania; Karlberg, Tobias; Bellocchi, Daniele; Llacuna, Laura; Macchiarulo, Antonio; Aaronson, Stuart A; Schueler, Herwig; Pellicciari, Roberto; Camaioni, Emidio
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2807 - 2812
反应条件
potassium dichromate; sulfuric acid T=20 - 45°C; 2.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/108707 A1, 2004 ;
Location in patent: Page 53 ;
WO 2004/108707 A1
反应条件
1: With acetic acid T=110 - 115°C; 3 h; 2: With sodium hydrogencarbonate in water pH=6;
参考文献
Linholter et al.
Acta Chemica Scandinavica (1947-1973), 1961 , vol. 15, p. 1660,1665
反应条件
1: With hydrazine hydrate in ethanol T=20°C; 24 h; 2: With acetic acid; sodium nitrite T=0°C;
参考文献
Katrusiak, Anna; Ratajczak-Sitarz, Malgorzata; Skierska, Urszula; Zinczenko, Wiktoria
Collection of Czechoslovak Chemical Communications, 2005 , vol. 70, # 9 p. 1372 - 1386
反应条件
1: aqueous methanol. NaOH 2: palladium/charcoal; aqueous NH3 / Hydrogenation 3: POCl3 View Scheme
参考文献
Takahayashi
Pharmaceutical Bulletin, 1957 , vol. 5, p. 229,233
