反应条件
1: N,N-dimethyl-formamide; water / 20 h / 20 °C / Inert atmosphere
2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 7 h / 20 °C
3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan
Patent: US2012/202785 A1, 2012 ;