1: BF3*Et2O 2: 68 percent / pyridine / 3 h / 0 °C 3: 89 percent / MS 4 A / CH2Cl2 / 1 h / -78 °C 4: 71 percent / Pd[P(Ph)3]4 / acetic acid / 80 °C 5: 75 percent / DBU / CH2Cl2 / 2 h / 0 °C 6: BF3*Et2O / CH2Cl2 / 25 °C 7: KOH / methanol / reflux View Scheme

1: p-TsOH / dimethylformamide 2: 73 percent / DCC; DMAP / CH2Cl2 / 20 °C 3: 87 percent / NIS; TMSOTf / CH2Cl2 / -30 - 20 °C 4: 92 percent / HOAc / H2O / 3 h / 80 °C 5: 93 percent / imidazole; DMAP / dimethylformamide / 20 °C 6: 58 percent / BF3*Et2O / CH2Cl2 / -40 - 20 °C 7: 95 percent / CAN / CH2Cl2; methanol / 1 h / 20 °C 8: 81 percent / NaOMe / methanol / 20 °C View Scheme

1: 92 percent / NaOMe / methanol / Heating 2: p-TsOH / dimethylformamide 3: 73 percent / DCC; DMAP / CH2Cl2 / 20 °C 4: 87 percent / NIS; TMSOTf / CH2Cl2 / -30 - 20 °C 5: 92 percent / HOAc / H2O / 3 h / 80 °C 6: 93 percent / imidazole; DMAP / dimethylformamide / 20 °C 7: 58 percent / BF3*Et2O / CH2Cl2 / -40 - 20 °C 8: 95 percent / CAN / CH2Cl2; methanol / 1 h / 20 °C 9: 81 percent / NaOMe / methanol / 20 °C View Scheme

1: 92 percent / TMSOTf / CH2Cl2 / 20 °C 2: NaOMe / methanol; CH2Cl2 / 20 °C 3: 60 percent / pyridine / 0 °C 4: 66 percent / TMSOTf / CH2Cl2 / 20 °C 5: 90 percent / NaOH / methanol; tetrahydrofuran; H2O / 40 °C View Scheme

1: 66 percent / TMSOTf / CH2Cl2 / 20 °C 2: 90 percent / NaOH / methanol; tetrahydrofuran; H2O / 40 °C View Scheme

1: 50 percent / 4A molecular sieves; NIS; AgOTf / CH2Cl2; toluene / 1 h / -30 °C 2: 85 percent / NaOMe / methanol; CH2Cl2 / 50 °C / pH 15 3: 64 percent / pyridine / 2 h / 20 °C 4: 100 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 5: 80 percent / TsOH*H2O / methanol; CH2Cl2 / 2 h / 20 °C 6: 75 percent / pyridine / CH2Cl2 / -20 °C 7: 89 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 8: 100 percent / NaOH; water / methanol; tetrahydrofuran / 5 h / 45 °C View Scheme

1: 100 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 2: 80 percent / TsOH*H2O / methanol; CH2Cl2 / 2 h / 20 °C 3: 75 percent / pyridine / CH2Cl2 / -20 °C 4: 89 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 5: 100 percent / NaOH; water / methanol; tetrahydrofuran / 5 h / 45 °C View Scheme

1: 85 percent / NaOMe / methanol; CH2Cl2 / 50 °C / pH 15 2: 64 percent / pyridine / 2 h / 20 °C 3: 100 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 4: 80 percent / TsOH*H2O / methanol; CH2Cl2 / 2 h / 20 °C 5: 75 percent / pyridine / CH2Cl2 / -20 °C 6: 89 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 7: 100 percent / NaOH; water / methanol; tetrahydrofuran / 5 h / 45 °C View Scheme

1: 75 percent / pyridine / CH2Cl2 / -20 °C 2: 89 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 3: 100 percent / NaOH; water / methanol; tetrahydrofuran / 5 h / 45 °C View Scheme

1: 80 percent / TsOH*H2O / methanol; CH2Cl2 / 2 h / 20 °C 2: 75 percent / pyridine / CH2Cl2 / -20 °C 3: 89 percent / 4A molecular sieves; BF3*OEt2 / CH2Cl2 / 1 h / -40 °C 4: 100 percent / NaOH; water / methanol; tetrahydrofuran / 5 h / 45 °C View Scheme