3-氨基-2,2二甲基乙酸合成路线 （共 19 条）
反应条件
ammonia in 1,4-dioxane T=60°C; P=2250.23 Torr; 16 h; Autoclave;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With sodium hydroxide in methanol T=50 - 53°C; 70 h; Sealed tube; 2: With hydrogenchloride in methanol; water T=0 - 20°C; 0.166667 h;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogenchloride Heating;
参考文献
Farmaco, Edizione Scientifica, , vol. 20, p. 428 - 445
反应条件
sodium hydroxide in methanol; water T=20°C; 16 h;
参考文献
WO2013/134660 A1, ;
Paragraph 0430 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 3 h;
参考文献
Sammet, Benedikt; Bogner, Tobias; Nahrwold, Markus; Weiss, Christine; Sewald, Norbert
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 6953 - 6960
反应条件
hydrogenchloride in acetic acid Hydrolysis; 16 h; Heating;
参考文献
Ducry, Laurent; Reinelt, Stefan; Seiler, Paul; Diederich, Francois; Bolin, David R.; Campbell, Robert M.; Olson, Gary L.
Helvetica Chimica Acta, 1999 , vol. 82, # 12 p. 2432 - 2447
反应条件
1: Raney nickel / Hydrogenation 2: aqueous Ba(OH)2 View Scheme
反应条件
1: hydrobromic acid 2: alcohol; ammonia / 0 °C / im geschlossenen Rohr zunaechst bei gewoehnlicher Temp. und dann bei 100grad View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 28, p. 1056
反应条件
acetic acid in tetrahydrofuran; water 1 h; Ambient temperature; Yield given;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 33, # 6 p. 2228 - 2234
反应条件
1: 77 percent / PPh3; DEAD / tetrahydrofuran / 20 h / 20 °C 2: 67 percent / aq. HCl / acetic acid / 16 h / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 82, # 12 p. 2432 - 2447
