5-氯-2,6-二甲氧基-4-甲基-8-硝基喹啉合成路线 （共 4 条）
反应条件
1: With phosphorous pentoxide in diethylphosphoric acid ethyl ester T=20°C; 1 h; Inert atmosphere; 2: With potassium nitrate in methanol; diethylphosphoric acid ethyl ester T=35°C; 0.25 h; RefluxInert atmosphere;
参考文献
Shiraki, Hiroaki; Kozar, Michael P.; Melendez, Victor; Hudson, Thomas H.; Ohrt, Colin; Magill, Alan J.; Lin, Ai J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 131 - 142
反应条件
potassium nitrate in methanol
参考文献
SmithKline Beecham p.l.c.; SmithKline Beecham Corporation
Patent: US6479660 B1, 2002 ;
反应条件
1.1: methanol / 43 h / Reflux; Inert atmosphere 2.1: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere 3.1: phosphorous pentoxide / diethylphosphoric acid ethyl ester / 1 h / 20 °C / Inert atmosphere 3.2: 0.25 h / 35 °C / Reflux; Inert atmosphere View Scheme
参考文献
Shiraki, Hiroaki; Kozar, Michael P.; Melendez, Victor; Hudson, Thomas H.; Ohrt, Colin; Magill, Alan J.; Lin, Ai J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 131 - 142
反应条件
1.1: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere 2.1: phosphorous pentoxide / diethylphosphoric acid ethyl ester / 1 h / 20 °C / Inert atmosphere 2.2: 0.25 h / 35 °C / Reflux; Inert atmosphere View Scheme
参考文献
Shiraki, Hiroaki; Kozar, Michael P.; Melendez, Victor; Hudson, Thomas H.; Ohrt, Colin; Magill, Alan J.; Lin, Ai J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 131 - 142
