反应条件
1: isobutyric acid ethyl ester With n-butyllithium; diisopropylamine in diethyl ether
T=-20 - 0°C; 1.5 h; Inert atmosphereSealed flask;
2: 1,2-bis(triflyloxy)ethane in diethyl ether
T=20°C; 25 h; Reflux;
参考文献
THE UNIVERSITY OF READING; LEWIS, Francis, William; HARWOOD, Laurence, Marius; HUDSON, Michael, James
Patent: WO2011/77081 A1, 2011 ;
Location in patent: Page/Page column 19-20 ;
