4-(三氟甲基)苯甲酰胺合成路线 （共 35 条）
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 38, # 7 p. 1197 - 1200
反应条件
1,10-phenanthroline; methyl-diethoxy-silane; ferrous acetate in toluene T=100°C; 28 h; Inert atmosphere; chemoselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 7 p. 1662 - 1666
反应条件
N-methyl-N-(trimethylsilyl)-trifluoroacetamide; copper(l) chloride in toluene T=100°C; 24 h;
参考文献
Enthaler, Stephan; Weidauer, Maik
Catalysis Letters, 2011 , vol. 141, # 8 p. 1079 - 1085
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; hydrogen; toluene-4-sulfonic acid; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in diethylene glycol dimethyl ether T=80°C; P=60006 Torr; 10 h; AutoclaveSchlenk techniqueInert atmosphere; Time;
参考文献
Raoufmoghaddam, Saeed; Drent, Eite; Bouwman, Elisabeth
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 717 - 733
反应条件
Rh(acac)(CO)2; hydrogen; toluene-4-sulfonic acid; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in diethylene glycol dimethyl ether T=100°C; P=37503.8 Torr; 8 h; Inert atmosphereSchlenk technique; chemoselective reaction;
参考文献
ChemSusChem, , vol. 6, # 9 p. 1759 - 1773
反应条件
calcium hydroxide powder; sodium hydroxide; sodium hypochlorite; benzyl alcohol in methanol; water; toluene
参考文献
Pfirmann; Ralf
Patent: US5410082 A1, 1995 ;
参考文献
McNeil-PPC, Inc.
Patent: US5342851 A1, 1994 ;
反应条件
Lawesson's reagent in toluene T=95°C; Inert atmosphere;
参考文献
Xu, Yali; Chen, Jiuxi; Gao, Wenxia; Jin, Huile; Ding, Jinchang; Wu, Huayue
Journal of Chemical Research, 2010 , # 3 p. 151 - 153
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; hydrogen; toluene-4-sulfonic acid; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in diethylene glycol dimethyl ether T=80°C; P=60006 Torr; 10 h; AutoclaveSchlenk techniqueInert atmosphere; Time;
参考文献
Raoufmoghaddam, Saeed; Drent, Eite; Bouwman, Elisabeth
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 717 - 733
反应条件
1: toluene; dioxane / Heating 2: LiAlH4 / diethyl ether View Scheme
参考文献
Malamas; Carlson; Grimes; Howell; Glaser; Gunawan; Nelson; Kanzelberger; Shah; Hartman
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 237 - 245
