Ni(PPh2Me)2Cl2 in tetrahydrofuran T=50°C; cross-coupling; 14 h;

1: With palladium diacetate in water T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; 2: With potassium hydroxide in water T=20 - 75°C; 1.5 h;

palladium diacetate in methanol T=25°C; 8 h;

1: 2,2'-dibromobiphenyl With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1.58333E-05 h; flow conditions; 2: methyl iodide in tetrahydrofuran; hexane T=0°C; 0.00272222 h; flow conditions; 3: methyl chloroformate Further stages;

NiCl2((PPh3)P)2; n-butyllithium; methylmagnesium bromide; zinc(II) chloride Yield given. Multistep reaction;

sodium hydroxide in ethanol 18 h; Ambient temperature;