5-溴-2-甲基-4-硝基-1H-咪唑合成路线 （共 14 条）
反应条件
sulfuric acid; nitric acid T=5 - 90°C; 1 h;
参考文献
PHARMINOX LIMITED; HUMMERSONE, Marc, Geoffery; COUSIN, David
Patent: WO2012/85501 A1, 2012 ;
Location in patent: Page/Page column 76 ;
反应条件
bromine; sodium hydrogencarbonate in N,N-dimethyl-formamide T=70°C; 2 h;
参考文献
Zink, Laura; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6991 - 6996
反应条件
in N,N-dimethyl-formamide T=100°C; 2.5 h;
参考文献
Synthesis, , # 18 p. 3150 - 3156
反应条件
in N,N-dimethyl-formamide T=100°C; 2.5 h;
参考文献
Neilde, Kevin; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice
Synthesis (Germany), 2013 , vol. 45, # 10 art. no. SS-2013-Z0114-OP, p. 1349 - 1356
反应条件
in diethyl ether T=20°C; 6 h;
参考文献
Zaprutko, Lucjusz; Zwawiak, Justyna; Olender, Dorota; Gzella, Andrzej
Heterocycles, 2012 , vol. 85, # 9 p. 2197 - 2211
参考文献
Kiselyov, Alexander S.; Piatnitski, Evgueni L.; Samet, Alexander V.; Kisliy, Victor P.; Semenov, Victor V.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1369 - 1375
反应条件
in diethyl ether T=20°C; 6 h;
参考文献
Zaprutko, Lucjusz; Zwawiak, Justyna; Olender, Dorota; Gzella, Andrzej
Heterocycles, 2012 , vol. 85, # 9 p. 2197 - 2211
反应条件
in N,N-dimethyl-formamide T=100°C; 2.5 h;
参考文献
Neilde, Kevin; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice
Synthesis (Germany), 2013 , vol. 45, # 10 art. no. SS-2013-Z0114-OP, p. 1349 - 1356
反应条件
in N,N-dimethyl-formamide T=100°C; 2.5 h;
参考文献
Synthesis, , # 18 p. 3150 - 3156
反应条件
sodium ethanolate in ethanol
Heating;
参考文献
Povstyanoi, M. V.; Klykov, M. A.; Klyuev, N. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981 , vol. 17, # 6 p. 622 - 626
Khimiya Geterotsiklicheskikh Soedinenii, 1981 , # 6 p. 833 - 837
