N-(4,5-二氯吡啶-2-基)-2,2-二甲基丙酰胺合成路线 （共 6 条）
反应条件
N-chloro-succinimide in acetonitrile 2 h; Heating;
参考文献
Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B.
Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870
反应条件
1: 95 percent / pyridine / 12 h / Ambient temperature 2: 95 percent / N-chlorosuccinimide / acetonitrile / 2 h / Heating View Scheme
参考文献
Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B.
Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870
反应条件
1: 95 percent / pyridine / 12 h / Ambient temperature 2: 95 percent / N-chlorosuccinimide / acetonitrile / 2 h / Heating View Scheme
参考文献
Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B.
Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870
反应条件
1: pyridine / 5 h / 20 °C 2: N-chloro-succinimide / acetonitrile / 5 h / 100 °C View Scheme
参考文献
HANMI PHARM. CO., LTD.; LEE, Kyung Ik; SIM, Jae Yi; KIM, Ho Seok; HA, Tae Hee; SUH, Kwee Hyun
Patent: WO2013/100631 A1, 2013 ;
反应条件
hydrogenchloride 10 h; Heating;
参考文献
Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B.
Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870
反应条件
sulfuric acid; nitric acid in water
T=35°C; 2.5 h; Acidic aqueous solution;
参考文献
ASTRAZENECA AB
Patent: WO2004/16611 A1, 2004 ;
Location in patent: Page 97-98 ;
WO 2004/016611 A1
