sodium hydroxide in ethanol; water 12 h; Heating;

formic acid; sodium cyanoborohydride in methanol; acetic acid

1: 89 percent / Br2; Ph3P; imidazole / CH2Cl2 / 1 h / 20 °C 2: 85 percent / K2CO3 / acetonitrile / 12 h / Heating 3: 99 percent / NaOH / ethanol; H2O / 12 h / Heating View Scheme

1: 85 percent / K2CO3 / acetonitrile / 12 h / Heating 2: 99 percent / NaOH / ethanol; H2O / 12 h / Heating View Scheme

1: 99 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating 2: 89 percent / Br2; Ph3P; imidazole / CH2Cl2 / 1 h / 20 °C 3: 85 percent / K2CO3 / acetonitrile / 12 h / Heating 4: 99 percent / NaOH / ethanol; H2O / 12 h / Heating View Scheme