1-(3-甲氧基苯基)环己醇合成路线 (共 4 条)
反应条件
1: in diethyl ether T=0 - 20°C; 4 h; 2: With water T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/50619 A1, 2004 ;
Location in patent: Page 74 ;
WO 2004/050619 A1
反应条件
1: 3-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-14°C; 0.166667 h; Inert atmosphere; 2: cyclohexanone in tetrahydrofuran T=-40°C; Inert atmosphere; 3: With water; ammonium chloride
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
[Rh(OH)(cycloocta-1,5-diene)]2; (+/-)-(6,6'-dimethoxybiphenyl-2,2'-diyl)bis{bis[2,6-bis(trifluoromethyl)-4-pyridyl]phosphine} in water; toluene T=20°C; 1 h; Inert atmosphere;
参考文献
Korenaga, Toshinobu; Ko, Aram; Uotani, Kotaro; Tanaka, Yuki; Sakai, Takashi
Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10703 - 10707
反应条件
sulfuric acid in acetic acid
参考文献
Balsamo,A. et al.
Tetrahedron, 1973 , vol. 29, p. 2183 - 2188