3-(5-甲酰基-2,4-二甲基-1H-吡咯-3-基)丙酸甲酯合成路线 （共 10 条）
反应条件
in 1,2-dichloro-ethane T=20°C; Formylation; 2 h;
参考文献
Sugen, Inc.
Patent: US6689806 B1, 2004 ;
Location in patent: Page/Page column 96 ;
US 6689806 B1
反应条件
trifluoroacetic acid; trimethyl orthoformate T=40°C; 0.166667 h;
参考文献
Lash, Timothy D.; Mani, Ukti N.; Lyons, Elizabeth A.; Thientanavanich, Pornlert; Jones, Marjorie A.
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 478 - 487
反应条件
1: H2 / Pd/C / ethanol / 2 h / 20 °C 2: TFA / 1 h / Heating 3: TFA / 1 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 17 p. 4812 - 4818
反应条件
1: With trifluoroacetic acid in dichloromethane 0.333333 h; 2: With orthoformic acid triethyl ester in dichloromethane T=4°C; 0.333333 h;
参考文献
Boiadjiev, Stefan E.; Lightner, David A.
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 1 p. 181 - 185
反应条件
in trifluoroacetic acid T=20°C; 0.166667 h;
参考文献
Taber; Nakajima
Journal of Organic Chemistry, 2001 , vol. 66, # 7 p. 2515 - 2517
反应条件
in trifluoroacetic acid T=0°C; 0.0833333 h;
参考文献
Al-Hazimi, Hassan M. G.; Jackson, Anthony H.; Knight, David W.; Lash, Timothy D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 265 - 276
反应条件
Multistep reaction.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 7 p. 2515 - 2517
反应条件
1: 48percent HBr / acetic acid / 0.17 h 2: 1) CuCl2, 2) conc. H2SO4 / 1) DMF, 140 deg C, 10 min, 2) 2 days View Scheme
参考文献
Chang
Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4610 - 4612
反应条件
1: 1) toluene-p-sulfonic acid hydrate, 2) HBr gas / 1) CH2Cl2, methanol, 40 min, 2) CH2Cl2
2: 1)trifluoroacetic acid 2) HBr/acetic acid / 1) 5 min 2) 1h
3: 1) copper(II) acetate 2) trifluoroacetic acid, conc. sulfuric acid / 1) dimethylformamide, 160deg C, 4 min 2) 45 min
View Scheme
参考文献
Smith, Kevin M.; Langry, Kevin C.; Minnetian, Ohannes M.
Journal of Organic Chemistry, 1984 , vol. 49, # 24 p. 4602 - 4609
