1.1: O3 / CH2Cl2; methanol / 1 h / -78 °C 1.2: Me2S / CH2Cl2; methanol / 1 h / -78 - 20 °C 2.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C 3.1: 0.49 g / HCl / diethyl ether / 0.5 h / 20 °C View Scheme

1.1: N-bromosuccinmide / dichloromethane / 3 h / Reflux 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.05 h / -60 °C 2.2: 0.25 h / -60 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / -60 - 20 °C 4.1: water; acetic acid / tetrahydrofuran / 0.5 h / 50 °C 5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.58 h / -48 °C 5.2: -48 - 20 °C 5.3: 0.5 h / 20 °C View Scheme

1.1: O3 / CH2Cl2; methanol / 1 h / -78 °C 1.2: Me2S / CH2Cl2; methanol / 1 h / -78 - 20 °C 2.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4028198', constants.ctx, '0')">copper(II) bis(trifluoromethanesulfonate)</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br />T=20&deg;C;&nbsp;8&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1744500', constants.ctx, '0')">carbamic acid 1,1-dimethylethyl ester</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '2349612', constants.ctx, '0')">boron trifluoride diethyl etherate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br />T=0 - 20&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;