反应条件
1.1: thionyl chloride / 3 h / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C 2.2: 24 h / 20 - 32 °C 3.1: sodium / methanol / 18 h / 0 - 20 °C 3.2: 4 h / 20 °C 4.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C View Scheme
参考文献
Bolli, Martin H.; Boss, Christoph; Binkert, Christoph; Buchmann, Stephan; Bur, Daniel; Hess, Patrick; Iglarz, Marc; Meyer, Solange; Rein, Josiane; Rey, Markus; Treiber, Alexander; Clozel, Martine; Fischli, Walter; Weller, Thomas
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7849 - 7861