(1R,5S,6R)-2,4-二氧代-3-氧杂双环[3.1.0]己烷-6-羧酸合成路线 （共 3 条）
反应条件
1.1: triethylamine / acetone / 3 h / 20 °C / Large scale reaction 1.2: 1 h / Reflux; Large scale reaction 2.1: sulfuric acid / 6 h / 60 °C / Large scale reaction 3.1: 15 - 30 °C 4.1: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1.1: triethylamine / acetone / 3 h / 20 °C / Large scale reaction 1.2: 1 h / Reflux; Large scale reaction 2.1: sulfuric acid / 6 h / 60 °C / Large scale reaction 3.1: 15 - 30 °C 4.1: 16 h / 30 °C / 3345.86 Torr 6.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 °C View Scheme
参考文献
Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062
反应条件
1.1: triethylamine / acetone / 3 h / 20 °C / Large scale reaction 1.2: 1 h / Reflux; Large scale reaction 2.1: sulfuric acid / 6 h / 60 °C / Large scale reaction 3.1: 15 - 30 °C 4.1: 16 h / 30 °C / 3345.86 Torr View Scheme
参考文献
Berliner, Martin A.; Makowski, Teresa; Ng, Karl; Sitter, Barbara; Wager, Carrie; Zhang, Yinsheng; Dubant, Stephane P. A.
Org. Process Res. Dev., 2011 , vol. 15, # 5 p. 1052 - 1062
