1: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 2: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 3: 74 percent / MnO2 / CH2Cl2 4: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 5: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 6: 1.) NaH / 1.) THF, 2.) THF, RT 7: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme

1: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 2: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 3: 74 percent / MnO2 / CH2Cl2 4: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 5: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 6: 1.) NaH / 1.) THF, 2.) THF, RT 7: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme

1: 69 percent / 80percent aq. HCOOH / hexane / Ambient temperature 2: 63 percent / DIBAL-H / CH2Cl2 / -78 °C 3: 74 percent / MnO2 / CH2Cl2 4: 55 percent / tetrahydrofuran / 0.5 h / 0 °C 5: 79 percent / MnO2 / CH2Cl2 / Ambient temperature 6: 1.) NaH / 1.) THF, 2.) THF, RT 7: 5N aq. KOH / methanol / 1 h / 60 °C View Scheme