(S)-(-)-4-(4-羟基苄基)-2-噁唑烷酮合成路线 (共 12 条)
反应条件
4-methyl-morpholine; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; sodium methylate; thiamine diphosphate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; Wang resin; diethylazodicarboxylate solid phase synthesis; var. quant. of boron reagent, Hunig base and aldehyde, temp.; Product distribution;
参考文献
Tetrahedron Letters, , vol. 38, # 51 p. 8777 - 8780
反应条件
4-methyl-morpholine; lithium hydroxide; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; thiamine diphosphate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; Wang resin; diethylazodicarboxylate solid phase synthesis; Multistep reaction;
参考文献
Purandare, Ashok V.; Natarajan, Sesha
Tetrahedron Letters, 1997 , vol. 38, # 51 p. 8777 - 8780
反应条件
hydrogen; palladium on activated charcoal in methanol; ethyl acetate
T=20°C; 12 h;
参考文献
Green, Rachel; Taylor, Piers J. M.; Bull, Steven D.; James, Tony D.; Mahon, Mary F.; Merritt, Andy T.
Tetrahedron Asymmetry, 2003 , vol. 14, # 17 p. 2619 - 2623
反应条件
potassium carbonate in toluene
4 h; Heating;
参考文献
Faita, Giuseppe; Paio, Alfredo; Quadrelli, Paolo; Rancati, Fabio; Seneci, Pierfausto
Tetrahedron, 2001 , vol. 57, # 39 p. 8313 - 8322
反应条件
1: LAH / tetrahydrofuran / 60 °C
2: NaOH / toluene
3: hydrogen / 10percent Pd/C / ethanol
View Scheme
参考文献
Purandare, Ashok V.; Natarajan, Sesha
Tetrahedron Letters, 1997 , vol. 38, # 51 p. 8777 - 8780
反应条件
1: NaOH / toluene
2: hydrogen / 10percent Pd/C / ethanol
View Scheme
参考文献
Purandare, Ashok V.; Natarajan, Sesha
Tetrahedron Letters, 1997 , vol. 38, # 51 p. 8777 - 8780
反应条件
1: 100 percent / SOCl2 / 48 h / 20 °C
2: K2CO3; NaHCO3 / H2O; CH2Cl2 / 2 h
3: 82 percent / NaBH4 / tetrahydrofuran / Heating
4: 50 percent / K2CO3 / toluene / 4 h / Heating
View Scheme
参考文献
Faita, Giuseppe; Paio, Alfredo; Quadrelli, Paolo; Rancati, Fabio; Seneci, Pierfausto
Tetrahedron, 2001 , vol. 57, # 39 p. 8313 - 8322
反应条件
1: 82 percent / NaBH4 / tetrahydrofuran / Heating
2: 50 percent / K2CO3 / toluene / 4 h / Heating
View Scheme
参考文献
Faita, Giuseppe; Paio, Alfredo; Quadrelli, Paolo; Rancati, Fabio; Seneci, Pierfausto
Tetrahedron, 2001 , vol. 57, # 39 p. 8313 - 8322
反应条件
1: K2CO3; NaHCO3 / H2O; CH2Cl2 / 2 h
2: 82 percent / NaBH4 / tetrahydrofuran / Heating
3: 50 percent / K2CO3 / toluene / 4 h / Heating
View Scheme
参考文献
Faita, Giuseppe; Paio, Alfredo; Quadrelli, Paolo; Rancati, Fabio; Seneci, Pierfausto
Tetrahedron, 2001 , vol. 57, # 39 p. 8313 - 8322
反应条件
1: aq. Na2CO3 / CHCl3
2: NaBH4
3: K2CO3 / toluene / Heating
View Scheme
参考文献
Faita, Giuseppe; Paio, Alfredo; Quadrelli, Paolo; Rancati, Fabio; Seneci, Pierfausto
Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1265 - 1269