3,3'-硫代二丙酰基二氯化物合成路线 （共 6 条）
反应条件
thionyl chloride in benzene Heating;
参考文献
Kosower; Radkowsky; Fairlamb; Croft; Neal
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 659 - 671
反应条件
a) 20 deg C, 1 h, b) reflux, 2 h;
参考文献
Vasil'eva, T. P.; Mozzhukhin, A. O.; Antipin, M. Yu.; Struchkov, Yu. T.
Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), 1992 , vol. 41, # 8.1 p. 1766 - 1775,1368 - 1376
反应条件
1: 76 percent / a) 20 deg C, 1 h, b) reflux, 2 h 2: 100 percent / 30percent aq. H2O2 / acetone; acetic acid View Scheme
参考文献
Vasil'eva, T. P.; Mozzhukhin, A. O.; Antipin, M. Yu.; Struchkov, Yu. T.
Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), 1992 , vol. 41, # 8.1 p. 1766 - 1775,1368 - 1376
反应条件
ammonia in water
Substitution; Heating;
参考文献
Gawandi; Mohan; Mittal
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 7 p. 1425 - 1432
反应条件
hydrogenchloride; triethylamine in diethyl ether
参考文献
LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
Patent: US6489318 B1, 2002 ;
参考文献
Copar, Anton; Prevec, Tadeja; Anzic, Borut; Mesar, Tomaz; Selic, Lovro; Vilar, Mateja; Solmajer, Tom
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 6 p. 971 - 975
