甲基 3-氰基-2-羟基-6-甲基异尼古丁酸酯合成路线 （共 6 条）
反应条件
sulfuric acid T=150°C; 0.0166667 h;
参考文献
Vasil'ev; Lyshchikov; Nasakin; Paramonov; Kayukov
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 10 p. 1537 - 1544
反应条件
hydrogenchloride in water 21 h; Reflux;
参考文献
Schmidt, Gunther; Reber, Stefan; Bolli, Martin H.; Abele, Stefan
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 595 - 604
反应条件
1: urea; acetic acid anhydride; HNO3 2: chlorobenzene; PCl5 3: iron; acetic acid 4: palladium/BaCO3; ethanol / Hydrogenation 5: concentrated aqueous HCl 6: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C 7: sodium borate; aluminium chloride; O,O'-dimethyl-diethylene glycol View Scheme
参考文献
Blackwood et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6244,6247
反应条件
1: urea; acetic acid anhydride; HNO3 2: chlorobenzene; PCl5 3: iron; acetic acid 4: platinum; aqueous HCl / Hydrogenation 5: H2O; aqueous NaNO2 / 70 °C 6: aluminium chloride; sodium borate; dimethyl ether View Scheme
参考文献
Blackwood et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6244,6247
反应条件
1: urea; acetic acid anhydride; HNO3
2: chlorobenzene; PCl5
3: iron; acetic acid
4: palladium/BaCO3; ethanol / Hydrogenation
5: concentrated aqueous HCl
6: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
View Scheme
参考文献
Blackwood et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6244,6247
反应条件
1: urea; acetic acid anhydride; HNO3
2: chlorobenzene; PCl5
3: iron; acetic acid
4: palladium/BaCO3; ethanol / Hydrogenation
5: concentrated aqueous HCl
View Scheme
参考文献
Blackwood et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 6244,6247
