1,3,5-三氯-2-硝基苯合成路线 （共 24 条）
反应条件
1: With sodium azide in dimethyl sulfoxide
T=20°C; 20 h;
2: With sodium tetrahydroborate; copper(II) sulfate in ethanol; dichloromethane
T=20°C; 1 h;
参考文献
Giannouli, Vasiliki; Kostakis, Ioannis K.; Pouli, Nicole; Marakos, Panagiotis; Kousidou, Olga Ch.; Tzanakakis, George N.; Karamanos, Nikos K.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1716 - 1719
反应条件
nitric acid in sulfuric acid
T=25 - 75°C;
参考文献
Moodie, Roy B.; Payne, Malcolm A.; Schofield, Kenneth
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 1457 - 1464
反应条件
nitric acid in various solvent(s)
T=25°C; Rate constantProduct distribution;
参考文献
Moodie, Roy B.; Payne, Malcolm A.; Schofield, Kenneth
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 1457 - 1464
反应条件
1: dimethyl sulfoxide; potassium fluoride / 180 °C
2: sulfuric acid; concentrated aqueous nitric acid / 50 - 70 °C
View Scheme
参考文献
Shaw,G.C.; Seaton,D.L.
Journal of Organic Chemistry, 1961 , vol. 26, p. 5227 - 5228
