2-氨基-5,6-二氯苯并咪唑合成路线 （共 7 条）
反应条件
in methanol; water; acetonitrile Ambient temperature;
参考文献
Townsend, Leroy B.; Devivar, Rodrigo V.; Turk, Steven R.; Nassiri, M. Reza; Drach, John C.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4098 - 4105
反应条件
hydrogenchloride; dihydrogen peroxide in water
参考文献
Pfizer Inc.
Patent: US4002623 A1, 1977 ;
反应条件
in methanol; water; acetonitrile
反应条件
1: 98 percent / H2, Raney nickel / ethanol / 2068.6 Torr 2: 91 percent / H2O; methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 8 p. 1252 - 1262
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) RT, 1 h, 2.) water, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Porcari, Anthony R.; Devivar, Rodrigo V.; Kucera, Louis S.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1252 - 1262
反应条件
copper dichloride; sodium nitrite 1.) RT, 2 h, 2.) H2O, 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Townsend, Leroy B.; Devivar, Rodrigo V.; Turk, Steven R.; Nassiri, M. Reza; Drach, John C.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4098 - 4105
反应条件
1: 1.) aq. NaNO2, CuCl2 / 1.) RT, 2 h, 2.) H2O, 100 deg C, 1 h
2: acetonitrile / 0.33 h / 75 °C
3: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 16 h / Ambient temperature
4: 74 percent / methanolic ammonia / Ambient temperature
View Scheme
参考文献
Townsend, Leroy B.; Devivar, Rodrigo V.; Turk, Steven R.; Nassiri, M. Reza; Drach, John C.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4098 - 4105
