2,4-二氨基-6-氯喹唑啉合成路线 (共 2 条)
反应条件
1: in sulfolane; dimethylsulfone T=165°C; 0.5 h; 2: With ammonia; water in sulfolane; dimethylsulfone pH=7 - 8;
参考文献
GILEAD SCIENCES, INC.
Patent: WO2008/9078 A2, 2008 ;
Location in patent: Page/Page column 60 ;
参考文献
Nelson; Rosowsky
Antimicrobial Agents and Chemotherapy, 2001 , vol. 45, # 12 p. 3293 - 3303