反应条件
1: 20 percent / AgF / acetonitrile / 18 h / in the dark 2: 60 percent / 6 M HCl / methanol / 1.) reflux, 3 h, 2.) room temp., 18 h 3: 5.2 g / 1.) Et3N, 2.) diphenyl phosphorazidate / 1.) room temp., 1 h, 2.) reflux, 18 h 4: 44 percent / 6 M HCl / tetrahydrofuran / 1.) 60 deg C, 3 h, 2.) room temp., 18 h 5: H2 / 20percent Pd/C / methanol / 18 h / 2585.7 Torr 6: 83 percent / Et3N / acetonitrile / 1.) reflux, 3 h, 2.) room temp., 18 h View Scheme
参考文献
Hagen; Domagala; Heifetz; Sanchez; Solomon
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854
