(R,R)-1,2-双(甲磺酰基氧基甲基)环己烷合成路线 （共 9 条）
反应条件
triethylamine in chloroform T=0 - 20°C; 5 h;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1.1: sulfuric acid / 18 h / 40 °C 2.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 2.2: 13 h / -5 - 40 °C 3.1: triethylamine / chloroform / 5 h / 0 - 20 °C View Scheme
反应条件
1.1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2.1: hydrogenchloride / water 3.1: sulfuric acid / 18 h / 40 °C 4.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 4.2: 13 h / -5 - 40 °C 5.1: triethylamine / chloroform / 5 h / 0 - 20 °C View Scheme
反应条件
1.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 1.2: 13 h / -5 - 40 °C 2.1: triethylamine / chloroform / 5 h / 0 - 20 °C View Scheme
反应条件
1.1: palladium; hydrogen / methanol / 30 - 35 °C 2.1: ethanol / 30 h / 35 - 75 °C 2.2: 1 h 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 65 °C 4.1: triethylamine / dichloromethane / 0.42 h / 25 - 35 °C / |Inert atmosphere 4.2: 3 h / -5 - 35 °C View Scheme
反应条件
1: Raney nickel; methanol / 50 - 60 °C / 73550.8 Torr / Hydrogenation.Behandeln des Reaktionsprodukts mit methanol. Natriummethylat 2: LiAlH4; diethyl ether 3: (1R)-menthyl isocyanate 4: pyridine View Scheme
参考文献
Journal of the Chemical Society, , p. 399,402
反应条件
1: (1R)-menthyl isocyanate 2: pyridine View Scheme
参考文献
Journal of the Chemical Society, , p. 399,402
反应条件
1: LiAlH4; diethyl ether 2: (1R)-menthyl isocyanate 3: pyridine View Scheme
参考文献
Journal of the Chemical Society, , p. 399,402
反应条件
sodium carbonate in acetonitrile T=80 - 85°C; 24 h;
参考文献
SHASUN PHARMACEUTICALS LIMITED; VIJAYABASKAR, V.; SRIMURUGAN, S.; KUMAR, R.V. Sathish; JAYAMANI, Munusamy
Patent: WO2013/190455 A2, 2013 ;
Location in patent: Page/Page column 13; 14 ;
