Boc-顺式-3-羟基-L-脯氨酸合成路线 （共 11 条）
反应条件
sodium hydroxide in tetrahydrofuran; water T=0 - 20°C;
参考文献
Thomas, Colin A.; Talaty, Erach R.; Bann, James G.
Chemical Communications, 2009 , # 23 p. 3366 - 3368
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 0.5 h; Ambient temperature;
参考文献
Goetschi, Erwin; Jenny, Christian-Johannes; Reindl, Peter; Ricklin, Fabienne
Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2219 - 2234
反应条件
sodium hydroxide in tetrahydrofuran 1 h;
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
1: 80 percent / aq. NaOH / tetrahydrofuran 2: diethyl ether 3: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 4: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
1: 80 percent / aq. NaOH / tetrahydrofuran 2: diethyl ether 3: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 4: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
1: diethyl ether 2: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 3: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
1: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 2: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
1: 84 percent / K2CO3 / dimethylformamide / 8 h / Ambient temperature 2: 97 percent / pyridine / 6 h / Ambient temperature 3: 90 percent / 48 h / Ambient temperature; Candida cylindraceae lipase, 0.1M sodium phosphate buffer (pH 7) 4: 89 percent / H2 / 5percent Pd/C / ethyl acetate / 0.5 h / Ambient temperature View Scheme
参考文献
Goetschi, Erwin; Jenny, Christian-Johannes; Reindl, Peter; Ricklin, Fabienne
Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2219 - 2234
反应条件
1.1: Cs2CO3 / dimethylformamide / 0 °C 1.2: 5.3 g / dimethylformamide / 20 °C 2.1: morph-DAST / tetrahydrofuran / -78 - 20 °C 3.1: H2 / Pd/C / methanol 4.1: HCl / dioxane / 1.5 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
trifluoroacetic acid T=0°C; 0.5 h;
参考文献
Helvetica Chimica Acta, , vol. 79, # 8 p. 2219 - 2234
