1: in N,N-dimethyl acetamide T=0 - 5°C; 1 h; Cooling with ice-methanol; 2: With acetic anhydride in N,N-dimethyl acetamide; toluene 1.5 h; Heating / reflux; Product distribution / selectivity;

1: benzene-1,4-dicarboxylic acid With thionyl chloride in toluene T=0 - 75°C; 7 h; 2: anthranilic acid in N,N-dimethyl acetamide; toluene T=0 - 5°C; 1 h; Cooling with ice-methanol; 3: With acetic anhydride in N,N-dimethyl acetamide; toluene 1.5 h; Heating / reflux; Product distribution / selectivity;

pyridine T=60°C;

acetic anhydride 12 h; Reflux; Product distribution / selectivity;

1: N,N-dimethyl-formamide / 60 °C 2: pyridine / 60 °C View Scheme

sodium hydroxide