2-(3-甲氧基-4-苯基甲氧基苯基)乙胺盐酸盐合成路线 （共 9 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2.5 h; Reflux; 2: With water in tetrahydrofuran T=0°C; 3: With hydrogenchloride in diethyl ether
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
1: With trifluoroacetic acid in dichloromethane T=0°C; 0.666667 h; 2: With sodium hydrogencarbonate in dichloromethane; water Cooling with ice; 3: With hydrogenchloride in diethyl ether
参考文献
Hwang, On-You; Chi, Dae-Yoon; Son, Hyo-Jin; Seo, Jai-Woong
Patent: US2010/217003 A1, 2010 ;
Location in patent: Page/Page column 6 ;
US 20100217003 A1
反应条件
hydrogenchloride in diethyl ether
参考文献
WO2008/69632 A1, ;
Page/Page column 12 ;
反应条件
1: 96.6 percent / NaBH4 / methanol / 3 h 2: 93.5 percent / thionyl chloride / diethyl ether / 6 h 3: dimethylformamide / 168 h / Ambient temperature 4: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme
参考文献
Phytochemistry, , vol. 46, # 1 p. 107 - 115
反应条件
1: 93.5 percent / thionyl chloride / diethyl ether / 6 h 2: dimethylformamide / 168 h / Ambient temperature 3: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme
参考文献
Phytochemistry, , vol. 46, # 1 p. 107 - 115
反应条件
1: dimethylformamide / 168 h / Ambient temperature 2: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme
参考文献
Phytochemistry, , vol. 46, # 1 p. 107 - 115
反应条件
1.1: potassium carbonate / acetone / 2 h / Reflux 2.1: ammonium acetate; acetic acid / 4 h / 90 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux 3.2: 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 15 p. 4862 - 4871
反应条件
1.1: potassium carbonate / acetone / 2 h / Reflux 2.1: ammonium acetate; acetic acid / 4 h / 90 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux 3.2: 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 15 p. 4862 - 4871
反应条件
hydrogenchloride; sodium tetrahydroborate; cobalt(II) chloride 1.) MeOH, 20 deg C, 1 h; Multistep reaction;
参考文献
Phytochemistry, , vol. 46, # 1 p. 107 - 115
