6-甲基-2-(三氟甲基)喹啉合成路线 （共 11 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.25 h;
参考文献
Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
反应条件
trichlorophosphate in n-heptane T=20 - 100°C; 6 h;
参考文献
Keller; Schlosser
Tetrahedron, 1996 , vol. 52, # 13 p. 4637 - 4644
反应条件
pyridine; copper(l) iodide in 1-methyl-pyrrolidin-2-one; ethyl acetate T=200 - 210°C; Inert atmosphere;
参考文献
Chen, Mao; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11628 - 11631
Angew. Chem., 2013 , vol. 125, # 44 p. 11842 - 11845,4
反应条件
in dichloromethane T=40°C; 6 h; Overall yield = 80 percent;
参考文献
El Kharrat, Salem; Laurent, Philippe; Blancou, Hubert
Tetrahedron, 2014 , vol. 70, # 6 p. 1252 - 1266
反应条件
in dichloromethane T=40°C; 6 h;
参考文献
El Kharrat, Salem; Laurent, Philippe; Blancou, Hubert
Tetrahedron, 2014 , vol. 70, # 6 p. 1252 - 1266
反应条件
in dichloromethane T=40°C; 12 h; Overall yield = 92 percent;
参考文献
El Kharrat, Salem; Laurent, Philippe; Blancou, Hubert
Tetrahedron, 2014 , vol. 70, # 6 p. 1252 - 1266
反应条件
in dichloromethane 12 h; Heating;
参考文献
El Kharrat, Salem; Skander, Myriem; Dahmani, Abdelkader; Laurent, Philippe; Blancou, Hubert
Journal of Organic Chemistry, 2005 , vol. 70, # 21 p. 8327 - 8331
反应条件
in acetic acid T=120°C; cyclocondensation; 8 h;
参考文献
Wang, Quan-Fu; Mao, Yun-Yu; Qin, Chao-Yue; Zhu, Shi-Zheng; Hu, Chang-Ming
Monatshefte fur Chemie, 2000 , vol. 131, # 1 p. 55 - 63
反应条件
1: 90 percent / CH2Cl2 / 2 h / 20 °C 2: acetic acid / 1,2-dichloro-ethane / 6 h / 80 °C View Scheme
参考文献
Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
反应条件
phosphorous pentoxide; phosphoric acid T=165°C; 36 h; Neat (no solvent);
参考文献
Bonacorso, Helio G.; Andrighetto, Rosalia; Krueger, Nicolas; Martins, Marcos A.P.; Zanatta, Nilo
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 8 p. 1426 - 1438
