2-氨基-5-甲基苯甲酸甲酯合成路线 （共 19 条）
反应条件
hydrazine in ethanol T=60°C; 15 h;
参考文献
Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I.
Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173
反应条件
hydrogenchloride; tetrafluoroboric acid; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
copper(l) iodide; diiodomethane; isopentyl nitrite in tetrahydrofuran T=70°C; 1.5 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB
Patent: EP1939202 A1, 2008 ;
Location in patent: Page/Page column 54-55 ;
反应条件
triethylamine in chloroform T=20°C; 8 h;
参考文献
Mori, Tatsuya; Ujihara, Kazuya; Matsumoto, Osamu; Yanagi, Kazunori; Matsuo, Noritada
Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1174 - 1181
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
1: 41 percent / POCl3 / CH2Cl2 / 19 h / 25 - 40 °C
2: 90 percent / LiHMDS / 3 h / -78 - 0 °C
View Scheme
参考文献
Lucas-Lopez, Cristina; Patterson, Stephen; Blum, Till; Straight, Aaron F.; Toth, Judit; Slawin, Alexandra M. Z.; Mitchison, Timothy J.; Sellers, James R.; Westwood, Nicholas J.
European Journal of Organic Chemistry, 2005 , # 9 p. 1736 - 1740
反应条件
hydrogenchloride; copper(I) bromide; sodium nitrite in water
T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
1: 83 percent / pyridine / 2 h / 25 °C
2: 1.) sodium hydride / 1.) DMF, <20 deg C, 30 min, 2.) 25 deg C, 2 h
3: 95 percent / phenol, HBr / acetic acid / 16.5 h / 25 °C
View Scheme
参考文献
Jones; Betteridge; Newell; Jackman
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1501 - 1507
反应条件
1: 82 percent / conc. HCl, CaCO3 / H2O; 1,2-dichloro-ethane / 1 h
2: 74 percent / ethanol / 1 h / Heating
3: 100percent N2H4*H2O / ethanol / 8 h / Heating
4: 69 percent / NaNO2, 5M HCl / 0.25 h
View Scheme
参考文献
Kennewell, Peter D.; Scrowston, Richard M.; Shenouda, Ibrahim G.; Tully, W. Roger; Westwood, Robert
Journal of Chemical Research, Miniprint, 1986 , # 7 p. 2001 - 2025
