4-氨基-3-甲基苯甲酸甲酯合成路线 （共 34 条）
反应条件
hydrazine hydrate; nickel in methanol T=20°C;
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
H2; palladium monocarbide in methanol
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: EP1109560 B1, 2003 ;
反应条件
sulfuric acid RefluxInert atmosphere;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 39 ;
US 20120277224 A1
参考文献
Szczepankiewicz; Chiou; Credo; Alder; Nukkala; Zielinski; Jarvis; Mollison; Frost; Bauch; Hui; Liu; Claiborne; Li; Rosenberg; Jae; Tasker; Gunawardana; Von Geldern; Gwaltney II; Wu-Wong; Gehrke
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4416 - 4430
反应条件
sodium tetrahydroborate; palladium on activated charcoal 1) THF, 20 min, -78 deg C, 2) 20 deg C, 8 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 43, # 18 p. 4221 - 4226
参考文献
Della Ca, Nicola; Motti, Elena; Mega, Antonio; Catellani, Marta
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 9 p. 1451 - 1454
反应条件
1: With hydrogenchloride; NH4BF4; sodium nitrite in water 0.583333 h; 2: With 18-crown-6 ether; potassium acetate in chloroform; water T=20°C; 2 h; Product distribution / selectivity;
参考文献
US2012/277224 A1, ;
Page/Page column 34 ;
US 20120277224 A1
反应条件
1: With sulfuric acid in water T=0°C; 2: With sodium nitrite in water T=0°C; 0.0833333 h; 3: With copper nitrate; urea; copper(II) oxide more than 3 stages;
参考文献
FERRING B.V.
Patent: WO2006/21213 A2, 2006 ;
Location in patent: Page/Page column 55 ;
WO 2006/021213 A2
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
trifluorormethanesulfonic acid; IPy2BF4 in dichloromethane T=20°C; Iodination; 16 h;
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
