5,6-二甲基噻吩[2,3-D]嘧啶-4(3H)-酮合成路线 （共 8 条）
反应条件
in formamide T=160°C; 6 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5992 - 5994
参考文献
Al-Taisan, Khulud M.; Al-Hazimi, Hassan M. A.; Al-Shihry, Shar S.
Molecules, 2010 , vol. 15, # 6 p. 3932 - 3957
反应条件
acetic acid; sodium nitrite in water
参考文献
Gakhar, H. K.; Gill, J. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 432 - 433
反应条件
1: 92 percent / 80percent N2H4*H2O / 0.17 h / Heating 2: 62 percent / NaNO2, AcOH / H2O View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 24, p. 432 - 433
反应条件
1: 67 percent / 1 h / Heating 2: 92 percent / 80percent N2H4*H2O / 0.17 h / Heating 3: 62 percent / NaNO2, AcOH / H2O View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 24, p. 432 - 433
反应条件
T=170°C; Inert atmosphere;
参考文献
Synthetic Communications, , vol. 41, # 19 p. 2835 - 2851
反应条件
thionyl chloride; N,N-dimethyl-formamide T=110°C; 3 h;
参考文献
EP1724268 A1, ;
Page/Page column 54 ;
反应条件
1: trichlorophosphate / 3 h / 90 °C / Inert atmosphere
2: ammonium hydroxide / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Sleebs, Brad E.; Nikolakopoulos, George; Street, Ian P.; Falk, Hendrik; Baell, Jonathan B.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5992 - 5994
