3-甲基-2-全氟丙基-1H-吲哚合成路线 （共 12 条）
反应条件
[S-BINAP]PdBr2; hydrogen in dichloromethane
T=120°C; P=41372.9 Torr; 24 h; Autoclave;
参考文献
Cabrera; Sharma; Ayala; Rubio-Perez; Amezquita-Valencia, Manuel
Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6758 - 6762
反应条件
2-Bromo-1,3,5-trimethyl-benzene; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=150°C; 2 h;
参考文献
Aoyagi, Yutaka; Shishikura, Masahiro; Mizusaki, Toshihiko; Komine, Takashi; Yoshinaga, Tokuji; Inaba, Haruko; Ohta, Akihiro; Takeya, Koichi
Heterocycles, 2008 , vol. 75, # 5 p. 1055 - 1059
反应条件
phosphorus trichoride in dichloromethane
3 h; Ambient temperature;
参考文献
Baccolini, Graziano; Bartoli, Giuseppe; Marotta, Emanuela; Todesco, Paolo E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2695 - 2697
反应条件
1: benzene / Heating
2: BF3OEt2 / CS2 / 48 h / 50 °C / various solvebts, Lewis acids; indolization in AcOH, temperature dependence; role of Lewis acid catalysts and solvents in the Fischer Indole synthesis
View Scheme
参考文献
Prochazka, Michal P.; Carlson, Rolf
Acta Chemica Scandinavica, 1989 , vol. 43, # 7 p. 651 - 659
反应条件
1: LiCl, benzoquinone, bis(benzonitrile)palladium(II) chloride / tetrahydrofuran / 48 h
2: 1.) PdCl2*2MeCN, Et3N, (i-Pr)2NLi, 2.) H2
View Scheme
参考文献
Hegedus, Louis S.; Winton, Peter M.; Varaprath Sudarsanan
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2215 - 2221
反应条件
1: Br2/Et3N / CH2Cl2
2: p-TSA
3: 1) lithium diisopropylamide / 1) THF, -78 deg C; 2) THF
4: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Vice, Susan F.; Gross, Edward A.; Friesen, Richard W.; Dmitrienko, Gary I.
Tetrahedron Letters, 1982 , vol. 23, # 8 p. 829 - 832
反应条件
1: 1) lithium diisopropylamide / 1) THF, -78 deg C; 2) THF
2: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Vice, Susan F.; Gross, Edward A.; Friesen, Richard W.; Dmitrienko, Gary I.
Tetrahedron Letters, 1982 , vol. 23, # 8 p. 829 - 832
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
Yield given;
参考文献
Vice, Susan F.; Gross, Edward A.; Friesen, Richard W.; Dmitrienko, Gary I.
Tetrahedron Letters, 1982 , vol. 23, # 8 p. 829 - 832
反应条件
mordenite in cyclohexane
Heating; Title compound not separated from byproducts;
参考文献
Prochazka, Michal P.; Eklund, Lars; Carlson, Rolf
Acta Chemica Scandinavica, 1990 , vol. 44, # 6 p. 610 - 613
反应条件
1: benzene / Heating
2: BF3OEt2 / CS2 / 48 h / 50 °C / various solvebts, Lewis acids; indolization in AcOH, temperature dependence; role of Lewis acid catalysts and solvents in the Fischer Indole synthesis
View Scheme
参考文献
Prochazka, Michal P.; Carlson, Rolf
Acta Chemica Scandinavica, 1989 , vol. 43, # 7 p. 651 - 659
