3-氨基-2-甲基苯甲酸甲酯合成路线 （共 12 条）
反应条件
hydrogen; palladium in methanol P=2585.81 Torr;
参考文献
WO2005/28445 A2, ;
Page/Page column 28 ;
WO 2005/028445 A2
反应条件
p-toluenesulfonic acid monohydrate; potassium carbonate in methanol; ethyl acetate
反应条件
sulfuric acid T=70°C; 22 h;
参考文献
WO2012/142513 A1, ;
Page/Page column 297 ;
WO 2012/142513 A1
反应条件
hydrogenchloride in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
反应条件
1: H2SO4 2: H2 / Pd-C / aq. ethanol; 2-methoxy-ethanol View Scheme
参考文献
Tetrahedron, , vol. 25, p. 4249 - 4256
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Haskins, Charlotte M.; Knight, David W.
Chemical Communications, 2005 , # 25 p. 3162 - 3164
反应条件
sodium nitrite in water; acetic acid
参考文献
Warner-Lambert Company
Patent: US6133303 A1, 2000 ;
US 6133303 A
反应条件
1.1: sodium nitrite; acetic acid / water 2.1: sodium hydroxide; water / methanol / 6 h / Reflux 2.2: Cooling with ice View Scheme
参考文献
Ochs, Raymond S.; Talele, Tanaji T.
Patent: US2012/130078 A1, 2012 ;
US 20120130078 A1
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5234946 A1, 1993 ;
反应条件
acetic acid; sodium nitrite in water
参考文献
US2012/130078 A1, ;
Page/Page column 4-5 ;
US 20120130078 A1
