(R)-3-(羰基甲基)-5-甲基己酸合成路线 （共 5 条）
反应条件
1: With sodium hydroxide in water T=30°C; 0.416667 h; 2: With bromine in water T=0 - 85°C; 1 h; 3: With hydrogenchloride in water T=0 - 90°C; 5 h; Product distribution / selectivity;
参考文献
WO2008/137512 A2, ;
Page/Page column 12 ;
反应条件
hydrogenchloride in water T=31°C; pH=1.7;
参考文献
WO2009/4643 A2, ;
Page/Page column 27 ;
反应条件
in ethanol; chloroform
T=30 - 55°C; 1 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/137512 A2, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
1: sodium hydroxide / dichloromethane; water / pH 10 - 11
2: chloroform / 0.5 h / 50 - 55 °C
View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; SATYANARAYANA, Revu
Patent: WO2011/77463 A1, 2011 ;
反应条件
1.1: urea / 12 h / 130 - 135 °C
1.2: 60 - 90 °C
2.1: chloroform / 0.5 h / 50 - 55 °C
View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; SATYANARAYANA, Revu
Patent: WO2011/77463 A1, 2011 ;
