1: With piperidine in dichloromethane; water T=22 - 25°C; 6 h; 2: With hydrogenchloride in water 20 h; Heating; 3: With acetic anhydride 2 h; Heating; Further stages.;
1: With quinidine T=-50°C; 17 h; 2: With ammonia in water T=20 - 40°C; 72 h; 3: With hydrogenchloride in water pH=3; Product distribution / selectivity;
1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 1.2: pH 2 2.1: acetone / water / 80 °C 3.1: ammonia / water / 5 h / 80 °C 3.2: 0 °C / pH 1 4.1: potassium hydroxide / water / 30 h / 0 °C 4.2: 1.17 h / 0 - 80 °C 4.3: 0.5 h / 80 - 90 °C View Scheme
参考文献
Dr. Braja Sundar Pradhan
Patent: WO2012/93411 A2, 2012 ;
1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 1.2: pH 2 2.1: acetone / water / 80 °C 3.1: ammonia / water / 5 h / 80 °C 3.2: 0 °C / pH 1 4.1: potassium hydroxide / water / 30 h / 0 °C 4.2: 1.17 h / 0 - 80 °C 4.3: 0.5 h / 80 - 90 °C View Scheme
参考文献
Dr. Braja Sundar Pradhan
Patent: WO2012/93411 A2, 2012 ;
