4-氨基-3-氟苯羧酸甲酯合成路线 (共 5 条)
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; ethyl acetate P=2068.65 Torr;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/16392 A2, 2007 ;
Location in patent: Page/Page column 48 ;
WO 2007/016392 A2
反应条件
thionyl chloride; palladium on charcoal in methanol; ethyl acetate
参考文献
US2003/158226 A1, ;
US 20030158226 A1
反应条件
1: hydrogenchloride / water / 16 h / Reflux 2: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 16 h / 30 °C / Inert atmosphere View Scheme
参考文献
WO2012/87519 A1, ;
WO 2012/087519 A1
反应条件
iodine cloride; calcium carbonate in ethanol; water T=20 - 25°C; 48 h;
参考文献
US2009/54427 A1, ;
Page/Page column 15-16 ;
反应条件
Oxonereg;; sodium bromide in water; acetonitrile T=25°C; 2 h;
参考文献
Briard, Emmanuelle; Lueoend, Rainer Martin; Machauer, Rainer; Moebitz, Henrik; Rogel, Olivier; Rondeau, Jean-Michel; Rueeger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob
Patent: US2009/54427 A1, 2009 ;
Location in patent: Page/Page column 15 ;