tributyl-amine; bis-triphenylphosphine-palladium(II) chloride T=110°C; P=7500.6 Torr; 2 h;

1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 50°C; Inert atmosphere; 2: 2,4-difluoro-benzoyl chloride in acetonitrile T=0 - 70°C; Inert atmosphere; 3: With hydrogenchloride in water; acetonitrile pH=5 - 6;

1.1: thionyl chloride / 2 h / |Reflux 2.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / |Inert atmosphere 2.2: 0 - 70 °C / |Inert atmosphere 2.3: pH 5 - 6 View Scheme