2-(3-溴-4-硝基苯基)乙酸甲酯合成路线 （共 8 条）
反应条件
trifluoroacetic acid in chloroform T=0 - 20°C; 5 h;
参考文献
Japan Tobacco Inc.
Patent: EP1669345 A1, 2006 ;
Location in patent: Page/Page column 88 ;
反应条件
nitric acid in sulfuric acid
参考文献
Daiichi Pharmaceutical Co., LTD.
Patent: US2003/78249 A1, 2003 ;
反应条件
sulfuric acid in chloroform 16 h;
参考文献
Radau, Gregor; Buellesbach, Ralf; Pachaly, Peter
Tetrahedron, 1996 , vol. 52, # 47 p. 14735 - 14744
反应条件
sulfuric acid; nitric acid T=0 - 20°C; 4 h;
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
反应条件
1: 99 percent / H2SO4 / 1,2-dichloro-ethane / 2 h / 80 °C 2: 29 percent / H2SO4; HNO3 / 4 h / 0 - 20 °C View Scheme
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
反应条件
1: 46 percent / konz. HNO3, konz. H2SO4 / 4 h / 5 - 10 °C 2: 89 percent / CH3COOH, conc. HCl / 2 h / Heating 3: 99 percent / H2SO4 / CHCl3 / 16 h View Scheme
参考文献
Radau, Gregor; Buellesbach, Ralf; Pachaly, Peter
Tetrahedron, 1996 , vol. 52, # 47 p. 14735 - 14744
反应条件
acetic acid in methanol; water
参考文献
Daiichi Pharmaceutical Co., LTD.
Patent: US2003/78249 A1, 2003 ;
反应条件
sodium acetate; iron; acetic acid in methanol; water T=110°C; 1 h;
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
